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     Publications     

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Clonal analysis of Notch1-expressing cells reveals the existence of unipotent stem cells that retain long-term plasticity in the embryonic mammary gland

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Cellular Plasticity of Mammary Epithelial Cells Underlies Heterogeneity of Breast Cancer

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How Lineage Tracing Studies Can Unveil Tumor Heterogeneity in Breast Cancer

2022

Lineage Tracing Methods to Study Mammary Epithelial Hierarchies In Vivo.
Rodilla V, Fre S.
Methods Mol Biol. 2022;2471:141-157. doi: 10.1007/978-1-0716-2193-6_7. PMID: 35175595.

How Lineage Tracing Studies Can Unveil Tumor Heterogeneity in Breast Cancer. 
Vinuesa-Pitarch E*, Ortega-Álvarez D*, Rodilla V.
Biomedicines 2022, 10(1), 3; https://doi.org/10.3390/biomedicines10010003

Therapy-Induced Senescence Enhances the Efficacy of HER2-Targeted Antibody-Drug Conjugates in Breast Cancer
Duro-Sánchez S, Nadal-Serrano M, Lalinde-Gutiérrez M, Arenas EJ, Bernadó Morales C, Morancho B, Escorihuela M, Pérez-Ramos S, Escrivá-de-Romaní S, Gandullo-Sánchez L, Pandiella A, Esteve-Codina A, Rodilla V, Dijcks FA, Dokter WHA, Cortés J, Saura C, Arribas J.
Cancer Res. 2022 Dec 16;82(24):4670-4679. doi: 10.1158/0008-5472.CAN-22-0787.

2020

LOXL2-mediated H3K4 oxidation reduces chromatin accessibility in triple-negative breast cancer cells.
Cebrià-Costa JP, Pascual-Reguant L, Gonzalez-Perez A, Serra-Bardenys G, Querol J, Cosín M, Verde G, Cigliano RA, Sanseverino W, Segura-Bayona S, Iturbide A, Andreu D, Nuciforo P, Bernado-Morales C, Rodilla V, Arribas J, Yelamos J, de Herreros AG, Stracker TH, Peiró S.
Oncogene. 2020 Jan;39(1):79-121. doi: 10.1038/s41388-019-0969-1. Epub 2019 Aug 28. PMID: 31462706; PMCID: PMC6937214.

Previous publications of current members

Identification and characterization of Cardiac Glycosides as senolytic compounds.
Triana-Martínez F, Picallos-Rabina P, Da Silva-Álvarez S, Pietrocola F, Llanos S, Rodilla V, Soprano E, Pedrosa P, Ferreirós A, Barradas M, Hernández-González F, Lalinde M, Prats N, Bernadó C, González P, Gómez M, Ikonomopoulou MP, Fernández-Marcos PJ, García-Caballero T, Del Pino P, Arribas J, Vidal A, González-Barcia M, Serrano M, Loza MI, Domínguez E, Collado M.
Nat Commun. 2019 Oct 21;10(1):4731. doi: 10.1038/s41467-019-12888-x. Erratum in: Nat Commun. 2020 Sep 16;11(1):4771. PMID: 31636264; PMCID: PMC6803708.

Could JAG1 protein inhibition prevent colorectal cancer?
López-Arribillaga E*, Rodilla V*, Espinosa L.
Future Oncol. 2019 Feb;15(4):345-347. doi: 10.2217/fon-2018-0760. Epub 2019 Jan 8. PMID: 30620224.

Cellular Plasticity of Mammary Epithelial Cells Underlies Heterogeneity of Breast Cancer.
Rodilla V#, Fre S#.
Biomedicines. 2018 Nov 1;6(4):103. doi: 10.3390/biomedicines6040103. PMID: 30388868; PMCID: PMC6315661.

Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells.
López-Arribillaga E*, Rodilla V*, Colomer C, Vert A, Shelton A, Cheng JH, Yan B, Gonzalez-Perez A, Junttila MR, Iglesias M, Torres F, Albanell J, Villanueva A, Bigas A, Siebel CW, Espinosa L.
Nat Commun. 2018 Jul 31;9(1):2992. doi: 10.1038/s41467-018-05385-0. PMID: 30065304; PMCID: PMC6068201.

Clonal analysis of Notch1-expressing cells reveals the existence of unipotent stem cells that retain long-term plasticity in the embryonic mammary gland.
Lilja AM*, Rodilla V*#, Huyghe M, Hannezo E, Landragin C, Renaud O, Leroy O, Rulands S, Simons BD, Fre S#.
Nat Cell Biol. 2018 Jun;20(6):677-687. doi: 10.1038/s41556-018-0108-1. Epub 2018 May 21. PMID: 29784917; PMCID: PMC6984964.

Impaired PRC2 activity promotes transcriptional instability and favors breast tumorigenesis. 
Wassef M, Rodilla V, Teissandier A, Zeitouni B, Gruel N, Sadacca B, Irondelle M, Charruel M, Ducos B, Michaud A, Caron M, Marangoni E, Chavrier P, Le Tourneau C, Kamal M, Pasmant E, Vidaud M, Servant N, Reyal F, Meseure D, Vincent-Salomon A, Fre S, Margueron R.
Genes Dev. 2015 Dec 15;29(24):2547-62. doi: 10.1101/gad.269522.115. Epub 2015 Dec 4. PMID: 26637281; PMCID: PMC4699384.

Luminal progenitors restrict their lineage potential during mammary gland development.
Rodilla V, Dasti A, Huyghe M, Lafkas D, Laurent C, Reyal F, Fre S.
PLoS Biol. 2015 Feb 17;13(2):e1002069. doi: 10.1371/journal.pbio.1002069. PMID: 25688859; PMCID: PMC4331521.

Bmi1 regulates murine intestinal stem cell proliferation and self-renewal downstream of Notch. 
López-Arribillaga E*, Rodilla V*, Pellegrinet L, Guiu J, Iglesias M, Roman AC, Gutarra S, González S, Muñoz-Cánoves P, Fernández-Salguero P, Radtke F, Bigas A, Espinosa L.
Development. 2015 Jan 1;142(1):41-50. doi: 10.1242/dev.107714. Epub 2014 Dec 5. PMID: 25480918.

Long range epigenetic silencing is a trans-species mechanism that results in cancer specific deregulation by overriding the chromatin domains of normal cells.
Forn M, Muñoz M, Tauriello DV, Merlos-Suárez A, Rodilla V, Bigas A, Batlle E, Jordà M, Peinado MA.
Mol Oncol. 2013 Dec;7(6):1129-41. doi: 10.1016/j.molonc.2013.08.008. Epub 2013 Aug 30. PMID: 24035705; PMCID: PMC5528435.

Notch3 marks clonogenic mammary luminal progenitor cells in vivo.
Lafkas D, Rodilla V, Huyghe M, Mourao L, Kiaris H, Fre S.
J Cell Biol. 2013 Oct 14;203(1):47-56. doi: 10.1083/jcb.201307046. Epub 2013 Oct 7. PMID: 24100291; PMCID: PMC3798243.

Chromatin-bound IκBα regulates a subset of polycomb target genes in differentiation and cancer. 
Mulero MC, Ferres-Marco D, Islam A, Margalef P, Pecoraro M, Toll A, Drechsel N, Charneco C, Davis S, Bellora N, Gallardo F, López-Arribillaga E, Asensio-Juan E, Rodilla V, González J, Iglesias M, Shih V, Mar Albà M, Di Croce L, Hoffmann A, Miyamoto S, Villà-Freixa J, López-Bigas N, Keyes WM, Domínguez M, Bigas A, Espinosa L. 
Cancer Cell. 2013 Aug 12;24(2):151-66. doi: 10.1016/j.ccr.2013.06.003. Epub 2013 Jul 11. PMID: 23850221; PMCID: PMC3962677.

Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells. 
Pellegrinet L, Rodilla V, Liu Z, Chen S, Koch U, Espinosa L, Kaestner KH, Kopan R, Lewis J, Radtke F.
Gastroenterology. 2011 Apr;140(4):1230-1240.e1-7. doi: 10.1053/j.gastro.2011.01.005. Epub 2011 Jan 14. PMID: 21238454; PMCID: PMC3066401.

The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemia.
Espinosa L, Cathelin S, D'Altri T, Trimarchi T, Statnikov A, Guiu J, Rodilla V, Inglés-Esteve J, Nomdedeu J, Bellosillo B, Besses C, Abdel-Wahab O, Kucine N, Sun SC, Song G, Mullighan CC, Levine RL, Rajewsky K, Aifantis I, Bigas A. 
Cancer Cell. 2010 Sep 14;18(3):268-81. doi: 10.1016/j.ccr.2010.08.006. PMID: 20832754; PMCID: PMC2963042.

Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer. 
Rodilla V, Villanueva A, Obrador-Hevia A, Robert-Moreno A, Fernández-Majada V, Grilli A, López-Bigas N, Bellora N, Albà MM, Torres F, Duñach M, Sanjuan X, Gonzalez S, Gridley T, Capella G, Bigas A, Espinosa L.
Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6315-20. doi: 10.1073/pnas.0813221106. Epub 2009 Mar 26. PMID: 19325125; PMCID: PMC2669348.

Efficient nuclear export of p65-IκBα complexes requires 14-3-3 proteins. 
Aguilera C, Fernández-Majada V, Inglés-Esteve J, Rodilla V, Bigas A, Espinosa L.
J Cell Sci. 2016 Jun 15;129(12):2472. doi: 10.1242/jcs.192641. Erratum for: J Cell Sci. 2006 Sep 1;119(Pt 17):3695-704. PMID: 27307493.

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